Pheromone-Based Calming Support for Cats & Dogs

Angels’ Eyes® Calming Line

Give your pet the peace they deserve.

Stress, anxiety, and behavioral issues don’t have to be your pet’s normal. Angels’ Eyes® Calming Line uses advanced pheromone technology — the same signals your pet naturally produces to feel safe — to help restore calm, reduce stress-related behaviors, and create a more harmonious home environment. Drug-free. Non-invasive. Trusted by pet parents and recommended by veterinarians.

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What are pheromones — and why do they matter?

Pheromones are chemical signals that animals produce and detect naturally. They’re invisible, odorless to humans, and communicate powerful messages between members of the same species — things like “this space is safe,” “I feel calm here,” or “everything is okay.” When your pet experiences stress — whether from a move, a new pet, a vet visit, or everyday anxiety — these natural calming signals can become disrupted or depleted. The result is often visible: hiding, scratching, urine marking, excessive grooming, or restlessness.

Our products release synthetic pheromones that are biologically identical to the ones your pet naturally produces in moments of comfort and security. When your pet senses them, the brain interprets the signal the same way it would a natural pheromone — creating a sense of familiarity, safety, and calm. There are no sedatives, no pharmaceuticals, and no behavioral side effects. Your pet remains fully alert, playful, and themselves — just without the anxiety.

Two types of pheromones.
One calming goal.

Not all pheromones are the same. Angels’ Eyes® uses two distinct pheromone types, each targeting a different layer of your cat’s emotional experience.

F3 Facial Pheromone (cats only)

When cats rub their cheeks against objects or people, they deposit F3 pheromones — a natural signal that means “this is mine, this is familiar, this is safe.” Our synthetic F3 pheromone replicates this marking behavior, helping your cat recognize their environment as secure and reducing the need to scratch or spray to claim territory.

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Maternal Appeasing Pheromone — MAP (cats and dogs)

MAP is the pheromone a mother cat/dog releases to their kittens/puppies to communicate comfort and reassurance. Even in adult pets, MAP helps promote emotional balance and social harmony. It’s particularly effective in multi-cat households where tension and competition between cats can disrupt the peace.

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Diffuser vs. Spray: which format is right for your pet?

Both formats work with the same pheromone technology — the difference is how and when you use them.

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Find the right product for your pet

Calm Cat Diffuser Kit

The most complete continuous calming solution for cats. Combines F3 Facial Pheromone and MAP in a plug-in system that delivers consistent, 24/7 pheromone coverage for up to 30 days. Ideal for cats experiencing anxiety due to environmental changes, new pets, or household tension.
• 30-day continuous pheromone release
• Combines F3 + MAP for full-spectrum calming
• Designed for multi-cat households
• Safe for cats of all ages
• Kit includes diffuser unit + one refill cartridge

Angels’ Eyes Calm Cat Diffuser Kit | 30-Day Pheromone
Angels’ Eyes Calm Cat Diffuser Kit | 30-Day Pheromone
Angels’ Eyes Calm Cat Diffuser Kit | 30-Day Pheromone
Angels’ Eyes Calm Cat Diffuser Kit | 30-Day Pheromone

Angels’ Eyes Calm Cat Diffuser Kit | 30-Day Pheromone

$33.49

Angels’ Eyes Calm Cat Calming Diffuser Kit delivers comprehensive feline anxiety relief through a dual-pheromone formula providing continuous 24/7 coverage for up to 30 days. This plug-in diffuser uses F3 facial pheromone and Maternal Appeasing Pheromone (MAP)—the two most powerful pheromone signals for feline stress relief. 

What’s Included 

One plug-in diffuser unit and one 30-day refill cartridge. Simply insert, plug in, and activate. Cartilage refills are also available in this link 

Key Benefits 

- Dual-pheromone formula: Powered by a premium blend of the F3 Feline Facial & Maternal Appeasing Pheromone  

- 30-day continuous release: No daily application needed 

- Multi-cat household solution: Establishes shared safe space 

- Drug-free and safe: No sedation or medications 

- Large coverage area: 750 sq.ft. 

- Odorless to humans: Cats receive full signal with no human-detectable scent 

- Can be used alongside sprays, spot-ons and chews for comprehensive calming care 

Who It’s For 

Ideal for multi-cat households experiencing territorial tension, single cats undergoing stressful transitions, rescue cats settling into new homes, and any household prioritizing proactive anxiety management. 

How to Use 

Choose a location where cats spend the most time. Plug into a standard wall outlet away from air vents or fans. Insert the 30-day refill cartridge. Leave running continuously. One unit covers 750 sq ft; larger homes may need additional units. Active within 2-4 hours. 

What to Expect 

Initial calming signs within 24-48 hours. Over 1-2 weeks: reduced spraying, decreased territorial aggression, improved confidence. By the end of the first refill, most households report dramatically reduced conflict. 

What Are Cat Pheromones — And How Does the Calm Cat Diffuser Help? 

Cat pheromones are natural chemical signals cats use to communicate safety, comfort, and territory with other felines. Cats have a specialized organ on the roof of their mouth that gives them 10x more scent receptors than humans, making pheromones essential to how they feel at home. 

The Calm Cat Diffuser mimics two of the most reassuring signals in a cat's world: the feline facial pheromone(released when your cat rubs their cheeks on furniture or your leg) and the feline maternal appeasing pheromone (the same comforting signal a mother gives her kittens). Together, they create an environment that feels safe 

 

Frequently Asked Questions 

Q: What’s the difference between F3 and MAP pheromones? 

A: F3 marks safe territory; MAP provides maternal comfort. Combined, they’re a more complete solution than single-pheromone products. 

Q: How many diffusers do I need? 

A: One per main living area. Multi-floor homes benefit from 2-3 units. 

Q: Is the diffuser safe to leave running 24/7? 

A: Completely safe. No heat hazards or electrical concerns with extended operation. 

Q: Can I use this with behavioral medications? 

A: Yes. Veterinarians often recommend pheromone diffusers alongside medications without interactions.

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Angels’ Eyes Calm Cat Diffuser Refill | 30-Day Pheromone
Angels’ Eyes Calm Cat Diffuser Refill | 30-Day Pheromone

Angels’ Eyes Calm Cat Diffuser Refill | 30-Day Pheromone

$25.49

Angels’ Eyes Calm Cat Calming Diffuser Refill maintains uninterrupted anxiety relief after your initial kit depletes. This refill cartridge contains the same dual-pheromone formula (F3 + MAP) in a convenient 30-day release vaporizer. Simply swap the depleted cartridge for a fresh refill to continue providing consistent calming pheromone coverage. 

How It Works 

The refill delivers the identical pheromone blend as the original kit. When inserted into your existing diffuser unit, it begins vaporizing within 2-4 hours, treating up to 750 sq ft continuously for 30 days. The dual-pheromone formula maintains behavioral improvements your cats achieved on the initial refill. 

Key Benefits 

- Same formula as kit:  F3 + MAP blend ensures consistent results 

- 30-day continuous coverage 

- Drop-in replacement: Simple cartridge swap 

- Helps Prevents behavioral regression 

Who It’s For 

Essential for any household already using the diffuser kit that wants to maintain continuous pheromone coverage. Multi-cat households, single cats in stressful environments, and any home that saw significant improvements with the initial kit. 

How to Use 

When the current refill has depleted (after 30 days), unplug the diffuser, remove the empty cartridge, insert the new refill, and plug back in. Active within 2-4 hours. Replace exactly on the 30-day schedule for optimal results. 

This is the diffuser refill, the kit with the diffuser can be found here. (link out to the kit)  

What to Expect 

Cats show immediate relaxation response within 4-8 hours. Behavioral responses are faster on subsequent refills since cats already recognize the pheromone signals. Any backsliding during gaps between refills reverses quickly. 

 

Frequently Asked Questions 

Q: Is the refill the same as the original kit cartridge? 

A: Yes, identical formula, potency, and effectiveness. 

Q: Can I store extra refills? 

A: Yes. Store unopened cartridges in a cool, dry location. Once activated, the 30-day countdown begins. 

Q: What if my cats’ behavior regresses between refill cycles? 

A: This indicates the diffuser is working! Replace the refill and improvement returns immediately. Reorder before current ones deplete. 

Q: How often should I replace the refill? 

A: Every 30 days for consistent results. Set calendar reminders to ensure uninterrupted coverage.

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Calm Cat Diffuser Refill

Same trusted formula as the original kit cartridge. Keep your home’s calming environment uninterrupted by replacing the cartridge every 30 days. Consistent use delivers consistent results — set a calendar reminder so you never run out.
• Identical formula and potency to the kit cartridge
• Replace every 30 days for uninterrupted coverage
• Store unopened cartridges in a cool, dry place

Calming Spray for Cats

Fast-acting pheromone spray for situational stress in cats. Apply directly to the environment — carrier, bedding, car seat, or furniture — for immediate calming support. Perfect for vet visits, travel, grooming sessions, or any sudden change in your cat’s routine.
• Fast-acting targeted calming support
• Ideal for travel, vet visits, and grooming
• 40–60 applications per 60ml bottle
• Safe for cats of all ages

Angels’ Eyes Calm Cat Spray | Feline Pheromone Relief
Angels’ Eyes Calm Cat Spray | Feline Pheromone Relief
Angels’ Eyes Calm Cat Spray | Feline Pheromone Relief
Angels’ Eyes Calm Cat Spray | Feline Pheromone Relief

Angels’ Eyes Calm Cat Spray | Feline Pheromone Relief

$29.99

Angels’ Eyes Calm Cat Calming Spray is a drug-free pheromone solution that addresses the root causes of feline anxiety and stress behaviors. This spray mimics natural feline  pheromones that cats produce. By restoring these calming signals, it helps reduces destructive scratching, unwanted spraying, excessive hiding, and aggression in multi-cat households. 

How It Works 

Angels' Eyes Calm Cat Spray is a simple and effective solution to reducing problem behavior in cats, such as inappropriate scratching and urination, or general feelings of anxiety. This handy spray is perfect for use anywhere around the home, and can be sprayed directly onto your cat's bedding, helping them feel settled and preventing destructive behavior. Angels' Eyes Calm Cat 

 Spray contains a copy of the naturally produced Feline Facial Pheromone, which is instantly recognizable to cats, and gives a continuous and reassuring message to let them know that this a safe area for them to be in. This can be especially beneficial when there are changes to a cat's environment, such as moving house, a new addition to the family or even new furniture in the home. Ideal for everyday use, during events such as fireworks or parties, and is especially useful in cat carriers during stressful travel or trips to the vet. Each application lasts for up to 5 hours. Suitable for cats of all ages. 

Key Benefits 

- Stops spraying and marking: Addresses behavioral causes of inappropriate urination 

- Reduces destructive scratching: Eliminates anxiety-driven claw sharpening 

- Decreases hiding behavior: Helps anxious cats feel secure enough to engage 

- Drug-free formula: No side effects, medications, or behavioral suppression 

- Multi-cat harmony: Reduces tension and territorial conflicts between cats 

Who It’s For 

Ideal for cats showing behavioral issues or signs of stress, cats undergoing veterinary care, and felines adjusting to household changes. Anxious cats prone to hiding, cats that spray excessively, and rescue cats adjusting to a new home all respond well to pheromone therapy. 

How to Use 

Use approximately 9 sprays per application. Angels' Eyes Calm Cat Spray lasts up to five hours and can be reapplied as necessary.  

- When using  for a cat carrier, bed, or a similar area, you must wait 15 minutes before placing your cat on or inside. Never spray directly onto the cat.   

- Can be Spraye on cat flaps to encourage use 

- Can be spray on targeted areas to help prevent marking or unwanted spraying 

- Can be sprayed on window ledges to help reduce general anxiety caused by neighborhood cats 

- Don't spray scratching posts, scratching boxes or scratch mats as this may prevent your cat from using them 

What to Expect 

Most cats show behavioral improvements within 24-48 hours—reduced spraying incidents, less destructive scratching, and increased confidence exploring their environment. Consistent application yields the best long-term results. 

Active Ingredient(s): 

 Feline Facial Pheromone

Frequently Asked Questions  

Q: Will this spray actually stop my cat from spraying? 

A: 70-85% of cats show significant improvement within 2-4 weeks of consistent application, especially when combined with litter box management and environmental enrichment. 

Q: Can I use this in a multi-cat household? 

A: Yes, specifically recommended for multi-cat homes. Spray around each cat’s resource areas to establish individual safe zones. 

Q: How does this compare to the Calm Cat diffuser? 

A: Spray provides immediate, portable application. Diffusers offer continuous 24/7 coverage. Many cat owners use both. 

Q: Will my cat be sedated or act differently? 

A: No. Cats remain fully alert and playful. The pheromone simply reduces anxiety, allowing your cat’s natural confidence to emerge.

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Angels’ Eyes Calm Dog Spray | Drug-Free Pheromone
Angels’ Eyes Calm Dog Spray | Drug-Free Pheromone
Angels’ Eyes Calm Dog Spray | Drug-Free Pheromone
Angels’ Eyes Calm Dog Spray | Drug-Free Pheromone

Angels’ Eyes Calm Dog Spray | Drug-Free Pheromone

$29.99

Reduce dog anxiety instantly with Angels' Eyes Calm Dog Spray. Drug-free DAP pheromone formula — works immediately for travel, vet visits, new homes, training and more. 

How It Works 

Calm Dog Spray contains Dog Appeasing Pheromone (DAP), a copy of the pheromone naturally produced by nursing mother dogs. It signals safety and comfort to dogs of all ages. By replicating these calming signals, Calm Dog Spray helps improve your dog's mood and reduces stress-induced behaviors whether at home or on the move. And unlike many solutions, it works immediately. 

Key Benefits

- Drug-free and non-sedating 

- Works immediately: Fast-acting pheromone formula takes effect right away 

- Long-lasting effects: A single application lasts up to five hours, with easy reapplication as needed 

- Universal application: Safe for all dog breeds, sizes, and ages, from puppies to seniors 

- Vet-recommended: Suggested by veterinarians for anxiety and behavioral management 

- Versatile use: Effective at home, in the car, at the vet, for training, and beyond 

Who It’s For 

Suitable for dogs of all ages and breeds. Ideal for anxious dogs during travel, car rides, thunderstorms, fireworks, veterinary visits, grooming appointments, and household changes. Puppies and rescue dogs adjusting to new homes,  dogs with separation anxiety, and senior dogs experiencing environmental stress all respond well to DAP therapy. 

How to Use 

Shake before each use. Spray approximately 9 sprays per application. Spray directly onto bedding, blanket, or crate 10-15 minutes before the stressful event. Angels' Eyes Calm Dog Spray lasts up to five hours and can be reapplied as necessary. 

Don't spray dog carriers while the dog is inside. Don't spray directly onto the dog.  Make sure to always fully read the product leaflet and packaging before use. 

What to Expect 

Most dogs show signs of relaxation within 5-15 minutes—reduced panting, lower body tension, decreased vocalization. Unlike sedating medications, your dog remains alert and responsive while feeling noticeably calmer. 

Active Ingredients 

Dog Appeasing Pheromone analogue 2% 

Frequently Asked Questions 

Q: Is Calm Dog spray safe for puppies and senior dogs? 

A: Yes. This drug-free formula is completely safe for dogs of all ages. 

Q: Can I use this spray in my car or travel crate? 

A: Absolutely. Spray the crate, blanket, or seat covers 15 minutes before departure. 

Q: How long does one bottle last? 

A: One 1.5 oz bottle typically provides 40-60 applications (3-4 sprays each). 

Q: Will this drug-free spray actually work? 

A: DAP is backed by veterinary science and recommended by behavior specialists worldwide. Clinical studies show significant anxiety reduction in most dogs. 

Q: Can I combine this with medications my vet prescribed? 

A: Yes. Since this is non-pharmaceutical, there are no drug interactions. 

Q: What’s the difference between this and plug-in diffusers? 

A: Spray provides immediate, portable application. Diffusers offer continuous 24/7 environmental coverage. Many pet owners use both. 

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Calming Spray for Dogs

Drug-free, pheromone-based calming support for dogs in stressful situations. Backed by DAP (Dog Appeasing Pheromone) science and recommended by veterinary behavior specialists worldwide. Spray the crate, blanket, or car interior before travel or high-stress events for noticeable anxiety reduction.
• Based on DAP — backed by veterinary science
• Ideal for travel, thunderstorms, separation, and grooming
• 40–60 applications per bottle
• Safe for dogs and puppies of all ages
• No drug interactions — compatible with prescribed medications

Expert tips you won’t find on the label

Pheromone therapy works best when you know how to use it strategically. Here’s what experienced pet parents and veterinarians have learned:

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1. Use the diffuser and spray together for full coverage

The diffuser handles your home environment around the clock. The spray handles the moments when your pet leaves that environment — or when they need an extra layer of reassurance. Using both is especially effective during high-stress transitions like moving to a new home or introducing a new pet.

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2. How many diffusers does your home actually need?

One diffuser covers one main living area. For multi-floor homes or large open-plan spaces, two to three units positioned in the areas where your cat spends the most time will deliver significantly better results than a single unit trying to cover the whole house.

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3. Spray the carrier 15 minutes before travel — not right before

The pheromones need a few minutes to settle and disperse before they’re effective. Spray the inside of the carrier or crate at least 15 minutes before you put your pet inside. Spraying at the last second is less effective than letting the environment absorb the pheromones first.

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4. In multi-cat households, spray each cat’s individual resource areas

Tension between cats often comes down to resource competition — food bowls, water stations, litter boxes, resting spots. In a multi-cat home, apply the spray around each cat’s individual resource areas to establish separate safe zones, rather than just spraying one central area.

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5. It works alongside prescribed medications

If your veterinarian has prescribed anti-anxiety medication for your pet, pheromone products are safe to use in combination. Many vets actively recommend this pairing — pheromones can enhance the effect of medication and may reduce the dosage needed over time. Always consult your vet for personalized guidance.

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6. Start the diffuser before the stressful event — not during

Pheromone therapy is most effective as a preventative measure. If you know a stressful event is coming — a renovation, a new baby, a new pet — start the diffuser at least a few days in advance so the environment is already saturated with calming signals when the change occurs.

Frequently asked questions

Will my cat or dog act differently or seem sedated?

No. Pheromones are not sedatives or pharmaceuticals. Your pet will remain fully alert, playful, and themselves. The pheromone simply reduces anxiety at a neurological level — allowing their natural confidence to come through without the stress overlay.

How quickly does it work?

The spray provides near-immediate effect — most pets respond within minutes of application. The diffuser builds up over several days. For ongoing behavioral issues, expect to see meaningful improvement within two to four weeks of consistent use.

Is it safe for kittens, puppies, and senior pets?

Yes. The formula is completely drug-free and safe for cats and dogs of all ages, including very young and very old animals. There are no dosage concerns because pheromones work at a sensory level, not a pharmaceutical one.

How long does one bottle of spray last?

Each 60ml bottle provides approximately 40 to 60 applications, using three to four sprays per session. For average use (a few applications per week), one bottle typically lasts one to two months.

Can I use the diffuser in a room with other pets or children?

The diffuser is completely safe for multi-pet households and around children. The pheromones are species-specific — they only communicate signals to cats, and have no effect on humans or other animals. Dogs will not respond to the cat pheromone diffuser, and vice versa.

What if my cat’s behavior doesn’t improve?

Pheromone therapy is effective for most stress-related behaviors, but some issues may have underlying medical or environmental causes. If you don’t see improvement after four to six weeks of consistent use, we recommend consulting your veterinarian to rule out other factors.

Is the diffuser refill the same formula as the kit?

Yes. The refill cartridge uses the exact same formula, potency, and concentration as the one included in the kit. There is no difference in effectiveness.

Can I use both the diffuser and the spray at the same time?

Absolutely — and many experienced pet parents do exactly that. The diffuser provides a continuous baseline of calming support in your home environment, while the spray handles specific high-stress moments outside that environment. Used together, they provide the most comprehensive pheromone coverage.

Ready to bring calm home?

Your pet deserves to feel safe, comfortable, and at ease — every day, not just on good days. Angels’ Eyes® Calming Line gives you science-backed tools to make that possible, without pharmaceuticals and without side effects.

Where can you find our products?

Angels' Eyes® Calming products are available now at www.AngelsEyesOnline.com.

And the good news keeps coming — we'll soon be available on Amazon, Chewy, and Walmart, making it even easier to keep your pet's calm routine uninterrupted.